METABOLISM
MOTS-c — mitochondrial metabolic peptide
Also known as: Mitochondrial Open Reading Frame
MOTS-c is the first discovered peptide encoded in mitochondrial DNA (Lee 2015, USC). It acts as a mitokine — signalling from mitochondria to nucleus and tissues, regulating energy metabolism and insulin sensitivity.
99%+ purity · Janoshik HPLC verified
Prices
MOTS-c · 50mg
1 vial50€
5-pack200€
Mechanism
Activates AMPK in muscle and adipose, mimicking calorie restriction and exercise effects. Boosts glucose uptake and fat oxidation.
Data
Reynolds 2021: restored old mouse endurance to young-mouse levels. Higher MOTS-c levels associated with human longevity.
Protocol
Typical 5–10 mg SC 2–3×/week for 4–8 week cycles, often paired with aerobic training.
Frequently asked questions
Buy in EU?
Yes — research-grade only, EU shipping.
Pair with cardio?
Yes — both activate AMPK synergistically.
Research use only. Not for human consumption.